$13,790.00 – $13,990.00
The Conduct Science precise impactor is used to create and evaluate traumatic brain injury mechanisms in pre-clinical medical research.
This device allows researchers to induce traumatic brain injuries (TBIs) with parameters such as impact depth, velocity, and dwell time precisely controlled to ensure accurate damage to provide high efficiency, repeatability, and stability, ensuring the reproducibility of impact direction and injury position.
Moreover, the precise impactor assesses cord injury mechanisms effectively. It can be precisely locked and applied to the spinal cord, especially when combined with our spinal cord adapters designed for mice and rats.
The Conduct Science Stereotaxic Precise Spinal and Cortical Impactor induces traumatic brain injury (TBI) for injury modeling and is controlled by pneumatic and electric components to increase accuracy and reproducibility.
In addition, a unique sensor automatically detects the zero-interface reference point at the impact point before the start of the impact procedure, thus reducing the tedious process of manual zeroing, making for precise and highly reproducible injuries. Parameters such as striking speed, striking depth and striking dwell time can be saved making it more convenient for the user.
Standard cylindrical head hammers with different size are available, please enquire.
No. | Name | Description |
|---|---|---|
1 | Power Switch | 2 Master power switch of the equipment |
2 | Touch LCD Screen | Control operation and display are all done on the touch screen. |
3 | Upper/Lower Limit Switch | Limit the moving location of the machine frame. |
4 | Magnetic Grid Displacement Sensor | It can detect the moving location of the machine frame to control the striking depth. |
5 | Animal Contact Sensor | It has two clamps to realize zero calibration detection. |
6 | Motor Driven Parts | Moving components (as shown in the dashed box in the picture ) driven devices |
*To request a quote for the customizable model, please contact us.
Feature | Description |
|---|---|
Striking speed | 26 speeds, 0.5m/s~5.6m/s, resolution ratio 0.1m/s, (error ±0.2m/s) |
Striking dwell time | 0～5.00s, resolution ratio 0.01s |
Striking depth | 0~5.00mm, resolution ratio 0.01mm |
Input gas pressure range | 0.68Mpa~0.8Mpa |
Display screen | 4.3-inch LCD resistance type touch screen,480*272 pixels |
Communication port | NA |
Power adapter | Input: 100~240V AC, 50/60Hz,1.5A Max Output: 24V DC 2.2A |
Equipment input | 24V DC, 30W Max |
Safety alarm | Audible alarm, text guidance, fault reminder function for High/low airway pressure, pipe block, high PEEP value etc. |
Animal platform size | 380*255(unit: mm) |
X-Y axis travel range | X direction, 0mm~116mm;Y direction, 0mm~98mm |
No. | Adaptor for Traumatic Brain Injury (TBI) | Model |
|---|---|---|
1 | Rotational Mouse Adaptor, 60°Ear Bars | CS-RMA-68065 |
2 | Rotational Rat Adaptor, 18°Ear Bars | CS-RMA-68063 |
3 | Optional Precise Rotational Adapter For Mouse | CS-PRMA-69100-03 |
4 | Optional Precise Rotational Adapter For Rat | CS-PRMA-69100-04 |
No. | Adaptor for Spinal Cord | Model |
|---|---|---|
1 | Mouse Spinal Cord Adaptor | CS-MSA-68094 |
2 | Rat Spinal Cord Adaptor | CS-RSA-68095 |
No. | Switch TBI impactor to Spinal cord Impactor Needed Accessories | Model |
|---|---|---|
1 | Three-axis Micro-manipulation Rotatable Platform | CS-LD-40-01 |
2 | Precision Spinal Cord Impactor Zeroing Device | CS-PZD-68199 |
*To request a quote for the customizable model, please contact us.
No. | Name | Description |
|---|---|---|
1 | Mouse Spinal cord Striking adaptor | It´s used for the mouse (15-40g) spinal cord striking experiment |
2 | Rat Spinal cord striking adaptor | It´s used for the rat (175-300g) spinal cord striking experiment |
3 | U-shaped Brain striking bracket | It´s used for the animal brain striking experiment |
The stereotaxic impactor is pneumatically-driven to induce traumatic brain injury (TBI) induction for controlled cortical impact modeling. The stereotaxic impactor allows researchers to create a neurotrauma model with an unprecedented degree of reproducibility in impact direction and injury position. The equipment utilizes a pneumatic piston to deliver a precise and accurate injury to the neocortex to mimic significant physiological, histological, and behavioral aspects of traumatic brain injury and closed head injury.
Animal models have been widely used to evaluate mechanisms underlying brain trauma and to test novel therapies. The Controlled Cortical Impact (CCI) is the most commonly used and widely accepted prototype to study the physical, psychiatric, cognitive, emotional, social, and behavioral health problems following brain injury. The reason behind the popularity of CCI among neuroscientists is the scalability and the control over biomechanical parameters of brain tissues exposed to direct mechanical deformation that the tool offers.
The stereotaxic impactor provides researchers full control over biomechanical parameters of the brain injury: velocity, depth, dwell time, and the force of the tip to create a controlled cortical impact. In addition to the parameter’s control, the tool allows the researchers to customize tip size, geometry, and position to accommodate different species. Taken together, the customization and scalability of the device enable the understudies to address multiple histopathological and functional queries related to brain injury.
The pneumatic stereotaxic impactor is a cutting-edge device used for creating controlled cortical impact models for brain injury studies. The apparatus consists of a U-shaped solid and heavy bracket to mount the animal. The device has a small bore (19.75mm) corresponding to a pneumatic piston for the strike. The stereotaxic impactor comes with a variety of cylindrical flat head hammers having outer diameters: 1mm, 1.2mm, 1.5mm, 2mm, 2.5mm, 3mm, 4mm, and 5mm. A crossbar holds the stereotaxically adjustable cylinder for mounting different animal species allowing the tip to be aligned vertically or angled concerning the brain. This model can be used for traumatic brain injury research in small rodents such as rats and mice, please see our large animal Stereotaxic line for use with larger animal models
The piston utilizes the tips of different sizes and geometry to induce brain trauma in the neural tissue. The researchers can adjust the strike speed from 0.5m/s to 3m/s according to the research requirement. Furthermore, the stereotaxic impactor enables the experimenters to control the dwell time (time range 60s) and the strike depth (0-10mm) with time accuracy of 1ms and depth accuracy of 0.01mm. The apparatus supports a variety of gas supplies, containing 9/16 ʺ and φ8 fast connection, easy-to-connect oxygen tanks, or aerostatic press.
Traumatic brain injuries are researched on models and prototypes to evaluate underlying mechanisms and to test potential therapeutic candidates. To create the controlled cortical impact model for brain injury study following protocol should be followed.
Note: The outflow pressure should be 80 PSI while the inflow pressure should be between 90-110 PSI.
The controlled cortical impact model has revolutionized traumatic brain injury and neurotrauma research to study morphological, physiological, and histological responses to the brain injury. The model helps to observe cortical contusion, disruption of the blood-brain barrier, hippocampal cell loss, apoptosis, necrosis, inflammation, and overall brain volume loss. Our system can be used to study a wide range of injury-associated fields such as the following:
1. Traumatic Brain Injury (TBI)
2. Spinal Cord Injury (SCI)
3. Neuroplasticity Studies
4. Pain Research
5. Neurodegenerative Disease Models
6. Behavioral Studies
7. Pharmacological Testing
8. Gene Therapy Research
The stereotaxic impactor allows the researchers to study animals of all ages. It can be used to study the impact of the injury on an immature brain by using a smaller tip and by driving the tip less rooted in the cortical region. Furthermore, the device can not only be used to study CCI but also to evaluate the closed head injury and repetitive injury. Closed head injury and repetitive injury are relevant to many clinical populations including athletes, prisoners, armed personnel, and the victims of violence. The pneumatic impactor can be used to create sports-related models by generating rotational head acceleration in the test animals.
The stereotaxic impactor offers notable advantages to the researchers. However, there are some limitations associated with it. The strengths and weaknesses of the stereotaxic impactor are discussed as follows:
Osier, N. D., & Dixon, C. E. (2016). The Controlled Cortical Impact Model: Applications, Considerations for Researchers, and Future Directions. Neurol.
Osier, N., & Dixon, C. E. (2017). The Controlled Cortical Impact Model of Experimental Brain Trauma: Overview, Research Applications, and Protocol. Methods Mol Biol, 177-192.
| Species | Mouse, Rat |
|---|---|
| Brand | ConductScience |
| Gas Source: | ≥99.2% Nitrogen |
| Power Source_ Power Adaptor Input: | 100∼240V AC, 50/60Hz, 1.5A Max |
| Power Source_ Power Adaptor Output: | 24V DC 2.2A |
| Power Source_Equipment Input: | 24V DC, 30W Max |
| Working Environment_Storage temperature: | -20℃ – 55℃ |
| Working Environment_Working temperature: | 5℃ ∼ 40℃ |
| Relative humidity: | 20% – 80% RH, non-condensing |
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DISCLAIMER: ConductScience and affiliate products are NOT designed for human consumption, testing, or clinical utilization. They are designed for pre-clinical utilization only. Customers purchasing apparatus for the purposes of scientific research or veterinary care affirm adherence to applicable regulatory bodies for the country in which their research or care is conducted.
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